Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8ctc
Q-score: 0.55
Nat Commun (2023) 14 pp. 2579-2579 [ Pubmed: 37142617 DOI: doi:10.1038/s41467-023-38120-5 ]
- Sodium ion (22 Da, Ligand)
- Glutamic acid (147 Da, Ligand)
- Mercury (ii) ion (200 Da, Ligand)
- Water (18 Da, Ligand)
- Human eaat3 with glutamate bound (Complex from Homo sapiens)
- Excitatory amino acid transporter 3 (57 kDa, Protein from Homo sapiens)
Resolution: 3.42 Å
EM Method: Single-particle
Fitted PDBs: 8ctd
Q-score: 0.448
Nat Commun (2023) 14 pp. 2579-2579 [ Pubmed: 37142617 DOI: doi:10.1038/s41467-023-38120-5 ]
- Sodium ion (22 Da, Ligand)
- Glutamic acid (147 Da, Ligand)
- Mercury (ii) ion (200 Da, Ligand)
- Human eaat3 with glutamate bound (Complex from Homo sapiens)
- Excitatory amino acid transporter 3 (57 kDa, Protein from Homo sapiens)
Resolution: 2.44 Å
EM Method: Single-particle
Fitted PDBs: 8cua
Q-score: 0.607
Nat Commun (2023) 14 pp. 2579-2579 [ Pubmed: 37142617 DOI: doi:10.1038/s41467-023-38120-5 ]
- Potassium ion (39 Da, Ligand)
- Water (18 Da, Ligand)
- Mercury (ii) ion (200 Da, Ligand)
- Excitatory amino acid transporter 3 (57 kDa, Protein from Homo sapiens)
- Human eaat3 with potassium bound (Complex from Homo sapiens)
Resolution: 2.94 Å
EM Method: Single-particle
Fitted PDBs: 8cud
Q-score: 0.541
Nat Commun (2023) 14 pp. 2579-2579 [ Pubmed: 37142617 DOI: doi:10.1038/s41467-023-38120-5 ]
- Human eaat3 in 300mm kcl (Complex from Homo sapiens)
- Excitatory amino acid transporter 3 (57 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Human excitatory amino acid transporter3 protomer at outward facing (ofs) apo state, from 300 mm potassium data set (Complex from Homo sapiens)
Human excitatory amino acid transporter 3 (EAAT3) in an intermediate outward facing apo state
Resolution: 2.55 Å
EM Method: Single-particle
Fitted PDBs: 8cui
Q-score: 0.602
Nat Commun (2023) 14 pp. 2579-2579 [ Pubmed: 37142617 DOI: doi:10.1038/s41467-023-38120-5 ]
- Human eaat3 in nmdg-cl (Complex from Homo sapiens)
- Excitatory amino acid transporter 3 (57 kDa, Protein from Homo sapiens)
Resolution: 3.04 Å
EM Method: Single-particle
Fitted PDBs: 8cuj
Q-score: 0.506
Nat Commun (2023) 14 pp. 2579-2579 [ Pubmed: 37142617 DOI: doi:10.1038/s41467-023-38120-5 ]
- Human eaat3 in 150 mm nmdg-cl (Complex from Homo sapiens)
- Excitatory amino acid transporter 3 (57 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
Human excitatory amino acid transporter 3 (EAAT3) in an outward facing sodium-bound state
Resolution: 2.44 Å
EM Method: Single-particle
Fitted PDBs: 8cv2
Q-score: 0.597
Nat Commun (2023) 14 pp. 2579-2579 [ Pubmed: 37142617 DOI: doi:10.1038/s41467-023-38120-5 ]
- Sodium ion (22 Da, Ligand)
- Excitatory amino acid transporter 3 (57 kDa, Protein from Homo sapiens)
- Human eaat3 in 300mm nacl (Complex from Homo sapiens)
Resolution: 3.04 Å
EM Method: Single-particle
Fitted PDBs: 8cv3
Q-score: 0.557
Nat Commun (2023) 14 pp. 2579-2579 [ Pubmed: 37142617 DOI: doi:10.1038/s41467-023-38120-5 ]
Structure of human excitatory amino acid transporter 3 (EAAT3) in complex with HIP-B
Resolution: 3.34 Å
EM Method: Single-particle
Fitted PDBs: 7nsg
Q-score: 0.539
Baronina A, Pike ACW, Yu X, Dong YY, Shintre CA, Tessitore A, Chu A, Rotty B, Venkaya S, Mukhopadhyay SMM, Borkowska O, Chalk R, Shrestha L, Burgess-Brown NA, Edwards AM, Arrowsmith CH, Bountra C, Han S, Carpenter EP
To Be Published
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Ternary complex of excitatory amino acid transporter 3 with inhibitor hip-b (160 kDa, Complex from Homo sapiens)
- (-)-3-hydroxy-4,5,6,6a-tetrahydro-3ah-pyrrolo[3,4-d]isoxazole-6-carboxylic acid (172 Da, Ligand)
- Excitatory amino acid transporter 3 (53 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- (+)-3-hydroxy-4,5,6,6a-tetrahydro-3ah-pyrrolo[3,4-d]isoxazole-6-carboxylic acid (172 Da, Ligand)
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 6x2l
Q-score: 0.579
Qiu B, Matthies D, Fortea E, Yu Z, Boudker O
Sci Adv (2021) 7 [ Pubmed: 33658209 DOI: doi:10.1126/sciadv.abf5814 ]
- Inward facing heaat3 trimer (Complex from Homo sapiens)
- Excitatory amino acid transporter 3 (57 kDa, Protein from Homo sapiens)